凝胶胶囊成分药品供应商 | Dow Inc.

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用高质量原料成分强化您的口服剂配方产品

与其他剂型相比，消费者更喜欢明胶胶囊，因此这种形式的药物开发比以往任何时候都更加重要。

CARBOWAX™ SENTRY™ LPEG 和 MPEG 是药用辅料，可作为溶解活性药物成分 (API) 的亲水性填充剂用于制造胶囊，也可用作明胶胶囊涂层中的增塑剂。

CARBOWAX™ SENTRY™聚乙二醇 (PEG) 在胶囊制剂中的使用历史悠久，因为它们满足所有药典要求，并且：

当使用难溶性 API 时，我们的低分子量 PEG 可以促进明胶胶囊的配方
我们的低醛等级产品可以帮助您降低外壳交联的风险
我们的各级产品杂质含量低，使您的药物生产更加一致，保质期更长
可以通过降低配方中的乙二醇 (EG) 水平来帮助您改善残留溶剂特性。

我们的 PEG 符合制药应用所需的 USP-NF 和 EP 专论，我们还提供区域监管和技术支持。

可选低醛等级

最大程度减少明胶外壳的交联

低醛低乙二醇 PEG 300
低醛低乙二醇 PEG 400
低醛低乙二醇 PEG 600

遵循陶氏简单的操作指南，在整个加工过程中保持低 EG 水平

载体/填料

改善难溶性 API 的溶解度，您可以使用

5-50% CARBOWAX™ SENTRY™ PEG 300
5-50% CARBOWAX™ SENTRY™ PEG 400
5-50% CARBOWAX™ SENTRY™ PEG 600

难溶性 API 示例：阿昔洛韦

增塑剂

改善软质明胶胶囊外壳的弹性

5-30% CARBOWAX™ SENTRY™ PEG 300
5-30% CARBOWAX™ SENTRY™ PEG 400
5-50% CARBOWAX™ SENTRY™ PEG 600
5-30% CARBOWAX™ SENTRY™ PEG 1000
5-30% CARBOWAX™ SENTRY™ PEG 1450

配方中 PEG 的最佳量取决于其余成分。我们建议配方设计师计算其最佳剂量，我们可以为您提供指导

稳定剂

降低降解风险

0.1 – 1% VERSENE™ NA 依地酸二钠

EDTA 可防止氧化敏感药物的化学降解，该过程由明胶中的游离金属（如铁）催化。

资源

快速链接

产品

技术内容

cGMP PEG
满足您要求的 PEG

低醛等级 PEG

USP级
防腐剂—VERSENE™ NA

cGMP 聚乙二醇
PEG 胶囊、局部药和其它