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true

助力药用明胶胶囊配方

用高质量原料成分强化您的口服剂配方产品

与其他剂型相比,消费者更喜欢明胶胶囊,因此这种形式的药物开发比以往任何时候都更加重要。

CARBOWAX™ SENTRY™ LPEG 和 MPEG 是药用辅料,可作为溶解活性药物成分 (API) 的亲水性填充剂用于制造胶囊,也可用作明胶胶囊涂层中的增塑剂。

CARBOWAX™ SENTRY™聚乙二醇 (PEG) 在胶囊制剂中的使用历史悠久,因为它们满足所有药典要求,并且:

  • 当使用难溶性 API 时,我们的低分子量 PEG 可以促进明胶胶囊的配方
  • 我们的低醛等级产品可以帮助您降低外壳交联的风险
  • 我们的各级产品杂质含量低,使您的药物生产更加一致,保质期更长
  • 可以通过降低配方中的乙二醇 (EG) 水平来帮助您改善残留溶剂特性。

我们的 PEG 符合制药应用所需的 USP-NF 和 EP 专论,我们还提供区域监管和技术支持。
 

可选低醛等级
最大程度减少明胶外壳的交联
  • 低醛低乙二醇 PEG 300
  • 低醛低乙二醇 PEG 400
  • 低醛低乙二醇 PEG 600
遵循陶氏简单的操作指南,在整个加工过程中保持低 EG 水平
载体/填料
改善难溶性 API 的溶解度, 您可以使用
  • 5-50% CARBOWAX™ SENTRY™ PEG 300
  • 5-50% CARBOWAX™ SENTRY™ PEG 400
  • 5-50% CARBOWAX™ SENTRY™ PEG 600
难溶性 API 示例:阿昔洛韦
增塑剂
改善软质明胶胶囊外壳的弹性
  • 5-30% CARBOWAX™ SENTRY™ PEG 300
  • 5-30% CARBOWAX™ SENTRY™ PEG 400
  • 5-50% CARBOWAX™ SENTRY™ PEG 600
  • 5-30% CARBOWAX™ SENTRY™ PEG 1000
  • 5-30% CARBOWAX™ SENTRY™ PEG 1450
配方中 PEG 的最佳量取决于其余成分。我们建议配方设计师计算其最佳剂量,我们可以为您提供指导
稳定剂
降低降解风险
  • 0.1 – 1% VERSENE™ NA 依地酸二钠
EDTA 可防止氧化敏感药物的化学降解,该过程由明胶中的游离金属(如铁)催化。

 

资源