Deliver To:

  • Afghanistan
  • Albania
  • Algeria
  • Amer.Virgin Is.
  • American Samoa
  • Andorra
  • Angola
  • Anguilla
  • Antarctica
  • Antigua Barbuda
  • Argentina
  • Armenia
  • Aruba
  • Australia
  • Austria
  • Azerbaijan
  • Bahamas
  • Bahrain
  • Bangladesh
  • Barbados
  • Belarus
  • Belgium
  • Belize
  • Benin
  • Bermuda
  • Bhutan
  • Bolivia
  • Bonaire, Saba
  • Bosnia-Herz.
  • Botswana
  • Bouvet Island
  • Brazil
  • Brit.Ind.Oc.Ter
  • Brit.Virgin Is.
  • Brunei Daruss.
  • Bulgaria
  • Burkina Faso
  • Burundi
  • C. African Rep.
  • Cambodia
  • Cameroon
  • Canada
  • Cape Verde
  • Cayman Islands
  • Chad
  • Chile
  • Christmas Islnd
  • Coconut Islands
  • Colombia
  • Comoros
  • Congo
  • Cook Islands
  • Costa Rica
  • Cote d'Ivoire
  • Croatia
  • Curacao
  • Cyprus
  • Czech Republic
  • Dem. Rep. Congo
  • Denmark
  • Djibouti
  • Dominica
  • Dominican Rep.
  • Ecuador
  • Egypt
  • El Salvador
  • Equatorial Guin
  • Eritrea
  • Estonia
  • Ethiopia
  • Falkland Islnds
  • Faroe Islands
  • Fiji
  • Finland
  • France
  • Frenc.Polynesia
  • French Guiana
  • French S.Territ
  • Gabon
  • Gambia
  • Georgia
  • Germany
  • Ghana
  • Gibraltar
  • Greater China (Chinese Mainland)
  • Greater China (Hong Kong SAR)
  • Greater China (Macau SAR)
  • Greater China (Taiwan)
  • Greece
  • Greenland
  • Grenada
  • Guadeloupe
  • Guam
  • Guatemala
  • Guinea
  • Guinea-Bissau
  • Guyana
  • Haiti
  • Heard McDon.Isl
  • Honduras
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Iraq
  • Ireland
  • Israel
  • Italy
  • Jamaica
  • Japan
  • Jordan
  • Kazakhstan
  • Kenya
  • Kiribati
  • Kosovo
  • Kuwait
  • Kyrgyzstan
  • Laos
  • Latvia
  • Lebanon
  • Lesotho
  • Liberia
  • Liechtenstein
  • Lithuania
  • Luxembourg
  • Madagascar
  • Malawi
  • Malaysia
  • Maldives
  • Mali
  • Malta
  • Marshall Islnds
  • Martinique
  • Mauritania
  • Mauritius
  • Mayotte
  • Mexico
  • Micronesia
  • Minor Outl.Isl.
  • Moldova
  • Monaco
  • Mongolia
  • Montenegro
  • Montserrat
  • Morocco
  • Mozambique
  • Myanmar
  • N.Mariana Islnd
  • Namibia
  • Nauru
  • Nepal
  • Netherlands
  • New Caledonia
  • New Zealand
  • Nicaragua
  • Niger
  • Nigeria
  • Niue
  • Norfolk Island
  • North Macedonia
  • Norway
  • Oman
  • Pakistan
  • Palau
  • Panama
  • Pap. New Guinea
  • Paraguay
  • Peru
  • Philippines
  • Pitcairn
  • Poland
  • Portugal
  • Puerto Rico
  • Qatar
  • Reunion
  • Romania
  • Russian Fed.
  • Rwanda
  • S. Sandwich Ins
  • S.Tome,Principe
  • Saint Helena
  • Saint Lucia
  • Samoa
  • San Marino
  • Saudi Arabia
  • Senegal
  • Serbia
  • Seychelles
  • Sierra Leone
  • Singapore
  • Sint Maarten
  • Slovakia
  • Slovenia
  • Solomon Islands
  • Somalia
  • South Africa
  • South Korea
  • Spain
  • Sri Lanka
  • St Kitts&Nevis
  • St. Vincent
  • St.Pier,Miquel.
  • Suriname
  • Svalbard
  • Swaziland
  • Sweden
  • Switzerland
  • Tajikistan
  • Tanzania
  • Thailand
  • Timor-Leste
  • Togo
  • Tokelau
  • Tonga
  • Trinidad,Tobago
  • Tunisia
  • Turkey
  • Turkmenistan
  • Turksh Caicosin
  • Tuvalu
  • Uganda
  • Ukraine
  • United Kingdom
  • United States
  • Uruguay
  • Utd.Arab Emir.
  • Uzbekistan
  • Vanuatu
  • Vatican City
  • Venezuela
  • Vietnam
  • Wallis,Futuna
  • West Sahara
  • Yemen
  • Zambia
  • Zimbabwe

Enabling Pharmaceutical Gel Capsule Formulations

Dietary supplement in soft gelatin capsule

Enabling Pharmaceutical Gel Capsule Formulations

Enhance your oral formulations with high quality ingredients

Consumers prefer gelatin capsules over other dosage forms, so the development of drugs in this form is more relevant than ever.

CARBOWAX™ SENTRY™ LPEG and MPEGs are pharmaceutical excipients which can be used in the manufacturing of capsules as hydrophilic fillers for solubilization of the Active Pharmaceutical Ingredient (API), but also as plasticizer in the coating of the gelatin capsules. 

EXPLORE MORE

CARBOWAX™ SENTRY™ Polyethylene Glycols (PEGs) have a long history of use in capsule formulations because they meet all compendial requirements and have the below benefits.

Lower molecular weight

Facilitating formulation of gelatin capsules when working with poorly soluble APIs.

Reduce risk of cross linking

Selecting our low aldehydes grades, helps reduce risk of cross linking of the shell.

Low impurity profiles

Allowing more consistent manufacturing and longer shelf-life of drugs.

Improved residual solvent profile

Lowering the Ethylene Glycol (EG) levels in your formulation. 

Meet USP-NF and EP monographs

Offering regional regulatory and technical support for pharmaceutical applications.

Blue gel pill capsules

Available low aldehyde grades

  • Minimize cross linking of the gelatin shell:
    • Low aldehyde and low ethylene glycol PEG 300
    • Low aldehyde and low ethylene glycol PEG 400
    • Low aldehyde and low ethylene glycol PEG 600
       
  • Maintain low EG levels throughout processing by following Dow’s simple handling guidance.
Process of production of pills, tablets

Carriers and filler

  • Improve the solubility of poorly soluble APIs by using:
    • 5-50% CARBOWAX™ SENTRY™ PEG 300
    • 5-50% CARBOWAX™ SENTRY™ PEG 400
    • 5-50% CARBOWAX™ SENTRY™ PEG 600
       
  • Example poorly soluble APIs: Acyclovir.
Blue soft gel capsule medicine in strip package with blur background

Plasticizers

  • Improve the elasticity of the soft gelatin capsule shells:
    • 5-30% CARBOWAX™ SENTRY™ PEG 300
    • 5-30% CARBOWAX™ SENTRY™ PEG 400
    • 5-50% CARBOWAX™ SENTRY™ PEG 600
    • 5-30% CARBOWAX™ SENTRY™ PEG 1000
    • 5-30% CARBOWAX™ SENTRY™ PEG 1450
       
  • The optimum quantity of the PEG in the formulation depends on the rest of the components. We recommend formulators to calculate their optimum dosage, and we are here to give guidance.
Generic Pill Bottle and Capsules

Stabilizers

  • Reduce degradation risks:
    • – 1% VERSENE™ NA Edetate Disodium
       
  • EDTA prevents chemical degradation of oxidation sensitive drugs which process is catalyzed by free metals in gelatin, such as iron.
  • Resources card image

    CARBOWAX™ & CARBOWAX™ SENTRY™ PEGs – Investing to ensure greater supply reliability.  

    VIEW PRODUCT GUIDE
  • Resources card image

    CARBOWAX™ SENTRY™ PEGs – Meeting increasingly stringent residual solvent limits. 

    VIEW GUIDE
  • Resources card image

    VERSENE™ NA Chelating Agent – Delivering an effective stabilizer and preservative for pharmaceutical preparations. 

    VIEW GUIDE
  • Resources card image

    CARBOWAX™ SENTRY™ PEG – Enabling formulations for cosmetics, pharmaceuticals and more. 

    VIEW GUIDE

    • Contact us to discuss your gelatin capsules challenges

    We are open to collaborate and support in solving any challenges you may have.

    CONTACT US